ChloroquineV1, Main, Exploration, bibRecord, 001A42

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Identifieur interne : 001A42 ( Main/Exploration ); précédent : 001A41; suivant : 001A43

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Auteurs : Masakazu Kono [Japon] ; Koichiro Tatsumi [Japon] ; Alberto M. Imai [Japon] ; Kengo Saito [Japon] ; Takayuki Kuriyama [Japon] ; Hiroshi Shirasawa [Japon]

Source :

Antiviral research [ 0166-3542 ] ; 2008.

RBID : Pascal:08-0128813

Descripteurs français

KwdFr :
- Antiviraux (pharmacologie), Cellules épithéliales (virologie), Chloroquine (pharmacologie), Coronavirus humain 229E (), Effet cytopathogène viral (), Extracellular Signal-Regulated MAP Kinases (antagonistes et inhibiteurs), Humains, Imidazoles (pharmacologie), Lignée cellulaire, Poumon (cytologie), Poumon (virologie), Pyridines (pharmacologie), RT-PCR, Réplication virale (), p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs).
MESH :
- antagonistes et inhibiteurs : Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases.
- cytologie : Poumon.
- pharmacologie : Antiviraux, Chloroquine, Imidazoles, Pyridines.
- virologie : Cellules épithéliales, Poumon.
Pascal (Inist)
- Coronavirus humain 229E, Effet cytopathogène viral, Homme, Coronavirus, Humains, Infection, Cellule épithéliale, Lignée cellulaire, Poumon, Chloroquine, RT-PCR, Réplication virale, p38 Mitogen activated protein kinase, Mitogen-activated protein kinase, Mécanisme action, Réplication, Antipaludique, Antiparasitaire, Antirhumatismal, Lignée L132.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antimalarial, Antirheumatic agent, Antiviral Agents (pharmacology), Cell Line, Chloroquine, Chloroquine (pharmacology), Coronavirus, Coronavirus 229E, Human (drug effects), Cytopathogenic Effect, Viral (drug effects), Epithelial Cells (virology), Epithelial cell, Extracellular Signal-Regulated MAP Kinases (antagonists & inhibitors), Human, Humans, Imidazoles (pharmacology), Infection, Lung, Lung (cytology), Lung (virology), Mechanism of action, Mitogen-activated protein kinase, Parasiticide, Pyridines (pharmacology), Replication, Reverse Transcriptase Polymerase Chain Reaction, Virus Replication (drug effects), p38 Mitogen activated protein kinase, p38 Mitogen-Activated Protein Kinases (antagonists & inhibitors).
MESH :
- chemical , antagonists & inhibitors : Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases.
- chemical , pharmacology : Antiviral Agents, Chloroquine, Imidazoles, Pyridines.
- cytology : Lung.
- drug effects : Coronavirus 229E, Human, Cytopathogenic Effect, Viral, Virus Replication.
- virology : Epithelial Cells, Lung.
- Cell Line, Humans, Reverse Transcriptase Polymerase Chain Reaction.

Abstract

The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.

Affiliations:

Japon

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarial</term>
<term>Antirheumatic agent</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Cell Line</term>
<term>Chloroquine</term>
<term>Chloroquine (pharmacology)</term>
<term>Coronavirus</term>
<term>Coronavirus 229E, Human (drug effects)</term>
<term>Cytopathogenic Effect, Viral (drug effects)</term>
<term>Epithelial Cells (virology)</term>
<term>Epithelial cell</term>
<term>Extracellular Signal-Regulated MAP Kinases (antagonists & inhibitors)</term>
<term>Human</term>
<term>Humans</term>
<term>Imidazoles (pharmacology)</term>
<term>Infection</term>
<term>Lung</term>
<term>Lung (cytology)</term>
<term>Lung (virology)</term>
<term>Mechanism of action</term>
<term>Mitogen-activated protein kinase</term>
<term>Parasiticide</term>
<term>Pyridines (pharmacology)</term>
<term>Replication</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Virus Replication (drug effects)</term>
<term>p38 Mitogen activated protein kinase</term>
<term>p38 Mitogen-Activated Protein Kinases (antagonists & inhibitors)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term>
<term>Cellules épithéliales (virologie)</term>
<term>Chloroquine (pharmacologie)</term>
<term>Coronavirus humain 229E ()</term>
<term>Effet cytopathogène viral ()</term>
<term>Extracellular Signal-Regulated MAP Kinases (antagonistes et inhibiteurs)</term>
<term>Humains</term>
<term>Imidazoles (pharmacologie)</term>
<term>Lignée cellulaire</term>
<term>Poumon (cytologie)</term>
<term>Poumon (virologie)</term>
<term>Pyridines (pharmacologie)</term>
<term>RT-PCR</term>
<term>Réplication virale ()</term>
<term>p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs)</term>
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<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Extracellular Signal-Regulated MAP Kinases</term>
<term>p38 Mitogen-Activated Protein Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Chloroquine</term>
<term>Imidazoles</term>
<term>Pyridines</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Extracellular Signal-Regulated MAP Kinases</term>
<term>p38 Mitogen-Activated Protein Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus 229E, Human</term>
<term>Cytopathogenic Effect, Viral</term>
<term>Virus Replication</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Chloroquine</term>
<term>Imidazoles</term>
<term>Pyridines</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Epithelial Cells</term>
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<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus humain 229E</term>
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<term>Homme</term>
<term>Coronavirus</term>
<term>Humains</term>
<term>Infection</term>
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<term>Chloroquine</term>
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<term>Réplication virale</term>
<term>p38 Mitogen activated protein kinase</term>
<term>Mitogen-activated protein kinase</term>
<term>Mécanisme action</term>
<term>Réplication</term>
<term>Antipaludique</term>
<term>Antiparasitaire</term>
<term>Antirhumatismal</term>
<term>Lignée L132</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Kono, Masakazu" sort="Kono, Masakazu" uniqKey="Kono M" first="Masakazu" last="Kono">Masakazu Kono</name>
</noRegion>
<name sortKey="Imai, Alberto M" sort="Imai, Alberto M" uniqKey="Imai A" first="Alberto M." last="Imai">Alberto M. Imai</name>
<name sortKey="Kono, Masakazu" sort="Kono, Masakazu" uniqKey="Kono M" first="Masakazu" last="Kono">Masakazu Kono</name>
<name sortKey="Kuriyama, Takayuki" sort="Kuriyama, Takayuki" uniqKey="Kuriyama T" first="Takayuki" last="Kuriyama">Takayuki Kuriyama</name>
<name sortKey="Saito, Kengo" sort="Saito, Kengo" uniqKey="Saito K" first="Kengo" last="Saito">Kengo Saito</name>
<name sortKey="Shirasawa, Hiroshi" sort="Shirasawa, Hiroshi" uniqKey="Shirasawa H" first="Hiroshi" last="Shirasawa">Hiroshi Shirasawa</name>
<name sortKey="Tatsumi, Koichiro" sort="Tatsumi, Koichiro" uniqKey="Tatsumi K" first="Koichiro" last="Tatsumi">Koichiro Tatsumi</name>
</country>
</tree>
</affiliations>
</record>

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Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

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Abstract

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